EP18. 徐圣进:漫谈吃喝拉撒睡这些“俗”事的脑科学

脑科学连线 BrainCast

公众号图文:https://mp.weixin.qq.com/s/AN_cd3dWMhbTXfBOemGM-w 嘉宾名片 徐圣进 博士 2012年博士毕业于中科院神经所。现为霍华德休斯医学研究所的珍妮亚研究园(HHMI/Janelia Research Campus)的研究科学家(Research Scientist)。将于今年的8月入职中科院神经所,担任生理稳态的神经机制研究组组长。研究组致力于从基因、基因表达、神经细胞反应活动、神经环路连接以及动物行为等多水平多尺度上全面系统地研究:1). 脑-体间交互(brain-body interaction)在调控各项基本生理指标(能量代谢,血糖、体温、血压、血氧、电解质、觉醒等)的动态稳定中的神经机制;2). 基本生理功能与高级脑功能(如情绪、社交、认知等)间相互作用的神经基础。联系方式:[email protected] 相关工作: 1. Shengjin Xu*, Wanchen Jiang*, Mu-ming Poo, Yang Dan. Activity recall in a visual cortical ensemble. Nature Neuroscience 15 (3), 449-455 (2012) (*co-first author) 2. J. Nicholas Betley*, Shengjin Xu*, Zhen Fang Huang Cao*, Rong Gong, Christopher J. Magnus, Yang Yu, Scott M. Sternson. Neurons for hunger and thirst transmit a negative-valence teaching signal. Nature 521 (7551), 180-185 (2015) (*co-first author, independent work on deep-brain imaging) 3. Scott M. Sternson, Deniz Atasoy, J. Nicholas Betley, Fredrick E. Henry, Shengjin Xu. An Emerging Technology Framework for the Neurobiology of Appetite. Cell Metabolism 23 (2), 234-253 (2016) 4. Carrie R Ferrario*, Gwenaël Labouèbe*, Shuai Liu*, Edward H Nieh*, Vanessa H Routh*, Shengjin Xu*, Eoin C O'Connor. Homeostasis Meets Motivation in the Battle to Control Food Intake. Journal of Neuroscience 36 (45), 11469-11481 (2016) (*co-first author) 5. Rong Gong, Shengjin Xu, Ann Hermundstad, Yang Yu, Scott M. Sternson. Hindbrain double-negative feedback mediates palatability-guided food and water consumption. Cell 182 (6), 1589-1605, (2020) 6. Shengjin Xu#, Hui Yang, Vilas Menon, Andrew L. Lemire, Lihua Wang, Fredrick E. Henry, Srinivas C. Turaga, Scott M. Sternson#. Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles. Science 370 (6514), (2020). (10-figure Enhanced Online Article, # co-corresponding author) 7. Yuhan Wang, Mark Eddison, Greg Fleishman, Martin Weigert, Shengjin Xu, Fredrick Henry, Tim Wang, Andrew Lemire, Uwe Schmidt, Hui Yang, Konrad Rokicki, Cristian Goina, Karel Svoboda, Eugene Myers, Stephan Saalfeld, Wyatt Korff, Scott M. Sternson#, Paul Tillberg#. Expansion-Assisted Iterative-FISH defines lateral hypothalamus spatio-molecular organization. BioRxiv preprint (doi.org), (2021).

45分钟
76
3个月前

EP16. 饶思圆:远程纳米磁控与脑机接口

脑科学连线 BrainCast

公众号图文:https://mp.weixin.qq.com/s/cfgIpiZvK10iWtHvaovajQ 嘉宾名片 饶思圆 博士 目前为麻省大学阿默斯特分校(Unviersity of Massachusettes, Amherst)助理教授,担任神经界面研究组 (Neurobiological Interfaces Laboratory) 组长。 2015年博士毕业于北京航空航天大学,2020年在麻省理工学院完成博士后训练。 博士和博士后期间主要从事磁控神经工程技术和生物器件的研究。 实验室主页链接:www.syraolab.com 联系方式:[email protected] 相关工作: * Rao, S.; Chen, R.; LaRocca, A. A.; Christiansen, M. G.; Senko, A. W.; Shi, C. H.; Chiang, P.-H.; Varnavides, G.; Xue, J.; Zhou, Y., Remotely controlled chemomagnetic modulation of targeted neural circuits. Nature nanotechnology 2019, 14 (10), 967-973. * Moon, J.; Christiansen, M. G.; Rao, S.; Marcus, C.; Bono, D. C.; Rosenfeld, D.; Gregurec, D.;Varnavides, G.; Chiang, P. H.; Park, S., Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling. Advanced Functional Materials 2020, 30 (36), 2000577. * Sun, X.; Bernstein, M. J.; Meng, M.; Rao, S.; Sørensen, A. T.; Yao, L.; Zhang, X.; Anikeeva, P. O.; Lin, Y., Functionally Distinct Neuronal Ensembles within the Memory Engram. Cell 2020. * Park, J.; Jin, K.; Sahasrabudhe, A.; Chiang, P.-H.; Maalouf, J. H.; Koehler, F.; Rosenfeld, D.; Rao, S.; Tanaka, T.; Khudiyev, T., In situ electrochemical generation of nitric oxide for neuronal modulation. Nature nanotechnology 2020, 15 (8), 690-697. * Lu, C.; Park, S.; Richner, T. J.; Derry, A.; Brown, I.; Hou, C.; Rao, S.; Kang, J.; Moritz, C. T.; Fink, Y., Flexible and stretchable nanowire-coated fibers for optoelectronic probing of spinal cord circuits. Science advances 2017, 3 (3), e1600955.

38分钟
29
3个月前

EP15. 赵郑拓:走近脑机接口和神经界面

脑科学连线 BrainCast

公众号图文:https://mp.weixin.qq.com/s/1_8VDOzDlt6abTey6HxHwg 嘉宾名片 [Image] 赵郑拓博士目前为中科院脑智卓越中心研究员,担任神经界面研究组组长。2019年毕业于德克萨斯大学奥斯汀分校,2020年在莱斯大学完成博士后训练。博士和博士后期间主要从事长期稳定,高带宽的脑神经界面开发,以及其在脑机接口中的应用。 相关工作: * F He, C Sullender, H Zhu, M Williamson, X Li, Z Zhao, T Jones, C Xie, A Dunn and L Luan (2020) Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes Science Advances 6: eaba1933 * Z Zhao, X Li, F He, X Wei, S Lin and C Xie (2019) Parallel, minimally-invasive implantation of ultra-flexible neural electrode arrays Journal of Neural Engineering 16: 35001 * CT Sullender, X Li, Z Zhao, H Zhu, X Wei, C Xie and AK Dunn (2018) Nanoelectronics enabled chronic multimodal neural platform in a mouse ischemic model Journal of Neuroscience Methods 295: 68-76 * X Wei#, L Luan#, Z Zhao#, X Li, H Zhu, O Potnis and C Xie (2018) Nanofabricated ultra-flexible electrode arrays for high-density intracortical recording Advanced Science 5: 1700625 * Z Zhao#, L Luan#, X Wei, H Zhu, X Li, S Lin, JJ Siegel, RA Chitwood, C Xie (2017) Nanoelectronic Coating Enabled Versatile Multifunctional Neural Probes Nano Letters 17: 4588–4595 * L Luan#, X Wei#, Z Zhao#, JJ Siegel, O Potnis, CA Tuppen, S Lin, S Kazmi, RA Fowler, S Holloway, AK Dunn, RA Chitwood, C Xie (2017) Ultraflexible nanoelectronic probes form reliable, glial scar free neural integration Science Advances 3: e1601966

35分钟
75
3个月前
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