脑科学连线 BrainCast - 节目列表

EP18. 徐圣进:漫谈吃喝拉撒睡这些“俗”事的脑科学

EP18. 徐圣进:漫谈吃喝拉撒睡这些“俗”事的脑科学

脑科学连线 BrainCast

公众号图文:https://mp.weixin.qq.com/s/AN_cd3dWMhbTXfBOemGM-w 嘉宾名片 徐圣进 博士 2012年博士毕业于中科院神经所。现为霍华德休斯医学研究所的珍妮亚研究园(HHMI/Janelia Research Campus)的研究科学家(Research Scientist)。将于今年的8月入职中科院神经所,担任生理稳态的神经机制研究组组长。研究组致力于从基因、基因表达、神经细胞反应活动、神经环路连接以及动物行为等多水平多尺度上全面系统地研究:1). 脑-体间交互(brain-body interaction)在调控各项基本生理指标(能量代谢,血糖、体温、血压、血氧、电解质、觉醒等)的动态稳定中的神经机制;2). 基本生理功能与高级脑功能(如情绪、社交、认知等)间相互作用的神经基础。联系方式:[email protected] 相关工作: 1. Shengjin Xu*, Wanchen Jiang*, Mu-ming Poo, Yang Dan. Activity recall in a visual cortical ensemble. Nature Neuroscience 15 (3), 449-455 (2012) (*co-first author) 2. J. Nicholas Betley*, Shengjin Xu*, Zhen Fang Huang Cao*, Rong Gong, Christopher J. Magnus, Yang Yu, Scott M. Sternson. Neurons for hunger and thirst transmit a negative-valence teaching signal. Nature 521 (7551), 180-185 (2015) (*co-first author, independent work on deep-brain imaging) 3. Scott M. Sternson, Deniz Atasoy, J. Nicholas Betley, Fredrick E. Henry, Shengjin Xu. An Emerging Technology Framework for the Neurobiology of Appetite. Cell Metabolism 23 (2), 234-253 (2016) 4. Carrie R Ferrario*, Gwenaël Labouèbe*, Shuai Liu*, Edward H Nieh*, Vanessa H Routh*, Shengjin Xu*, Eoin C O'Connor. Homeostasis Meets Motivation in the Battle to Control Food Intake. Journal of Neuroscience 36 (45), 11469-11481 (2016) (*co-first author) 5. Rong Gong, Shengjin Xu, Ann Hermundstad, Yang Yu, Scott M. Sternson. Hindbrain double-negative feedback mediates palatability-guided food and water consumption. Cell 182 (6), 1589-1605, (2020) 6. Shengjin Xu#, Hui Yang, Vilas Menon, Andrew L. Lemire, Lihua Wang, Fredrick E. Henry, Srinivas C. Turaga, Scott M. Sternson#. Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles. Science 370 (6514), (2020). (10-figure Enhanced Online Article, # co-corresponding author) 7. Yuhan Wang, Mark Eddison, Greg Fleishman, Martin Weigert, Shengjin Xu, Fredrick Henry, Tim Wang, Andrew Lemire, Uwe Schmidt, Hui Yang, Konrad Rokicki, Cristian Goina, Karel Svoboda, Eugene Myers, Stephan Saalfeld, Wyatt Korff, Scott M. Sternson#, Paul Tillberg#. Expansion-Assisted Iterative-FISH defines lateral hypothalamus spatio-molecular organization. BioRxiv preprint (doi.org), (2021).

45分钟
99+
10个月前
EP16. 饶思圆:远程纳米磁控与脑机接口

EP16. 饶思圆:远程纳米磁控与脑机接口

脑科学连线 BrainCast

公众号图文:https://mp.weixin.qq.com/s/cfgIpiZvK10iWtHvaovajQ 嘉宾名片 饶思圆 博士 目前为麻省大学阿默斯特分校(Unviersity of Massachusettes, Amherst)助理教授,担任神经界面研究组 (Neurobiological Interfaces Laboratory) 组长。 2015年博士毕业于北京航空航天大学,2020年在麻省理工学院完成博士后训练。 博士和博士后期间主要从事磁控神经工程技术和生物器件的研究。 实验室主页链接:www.syraolab.com 联系方式:[email protected] 相关工作: * Rao, S.; Chen, R.; LaRocca, A. A.; Christiansen, M. G.; Senko, A. W.; Shi, C. H.; Chiang, P.-H.; Varnavides, G.; Xue, J.; Zhou, Y., Remotely controlled chemomagnetic modulation of targeted neural circuits. Nature nanotechnology 2019, 14 (10), 967-973. * Moon, J.; Christiansen, M. G.; Rao, S.; Marcus, C.; Bono, D. C.; Rosenfeld, D.; Gregurec, D.;Varnavides, G.; Chiang, P. H.; Park, S., Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling. Advanced Functional Materials 2020, 30 (36), 2000577. * Sun, X.; Bernstein, M. J.; Meng, M.; Rao, S.; Sørensen, A. T.; Yao, L.; Zhang, X.; Anikeeva, P. O.; Lin, Y., Functionally Distinct Neuronal Ensembles within the Memory Engram. Cell 2020. * Park, J.; Jin, K.; Sahasrabudhe, A.; Chiang, P.-H.; Maalouf, J. H.; Koehler, F.; Rosenfeld, D.; Rao, S.; Tanaka, T.; Khudiyev, T., In situ electrochemical generation of nitric oxide for neuronal modulation. Nature nanotechnology 2020, 15 (8), 690-697. * Lu, C.; Park, S.; Richner, T. J.; Derry, A.; Brown, I.; Hou, C.; Rao, S.; Kang, J.; Moritz, C. T.; Fink, Y., Flexible and stretchable nanowire-coated fibers for optoelectronic probing of spinal cord circuits. Science advances 2017, 3 (3), e1600955.

38分钟
39
10个月前
EP15. 赵郑拓:走近脑机接口和神经界面

EP15. 赵郑拓:走近脑机接口和神经界面

脑科学连线 BrainCast

公众号图文:https://mp.weixin.qq.com/s/1_8VDOzDlt6abTey6HxHwg嘉宾名片赵郑拓博士目前为中科院脑智卓越中心研究员,担任神经界面研究组组长。2019年毕业于德克萨斯大学奥斯汀分校,2020年在莱斯大学完成博士后训练。博士和博士后期间主要从事长期稳定,高带宽的脑神经界面开发,以及其在脑机接口中的应用。相关工作: F He, C Sullender, H Zhu, M Williamson, X Li, Z Zhao, T Jones, C Xie, A Dunn and L Luan (2020) Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes Science Advances 6: eaba1933 Z Zhao, X Li, F He, X Wei, S Lin and C Xie (2019) Parallel, minimally-invasive implantation of ultra-flexible neural electrode arrays Journal of Neural Engineering 16: 35001 CT Sullender, X Li, Z Zhao, H Zhu, X Wei, C Xie and AK Dunn (2018) Nanoelectronics enabled chronic multimodal neural platform in a mouse ischemic model Journal of Neuroscience Methods 295: 68-76 X Wei#, L Luan#, Z Zhao#, X Li, H Zhu, O Potnis and C Xie (2018) Nanofabricated ultra-flexible electrode arrays for high-density intracortical recording Advanced Science 5: 1700625 Z Zhao#, L Luan#, X Wei, H Zhu, X Li, S Lin, JJ Siegel, RA Chitwood, C Xie (2017) Nanoelectronic Coating Enabled Versatile Multifunctional Neural Probes Nano Letters 17: 4588–4595 L Luan#, X Wei#, Z Zhao#, JJ Siegel, O Potnis, CA Tuppen, S Lin, S Kazmi, RA Fowler, S Holloway, AK Dunn, RA Chitwood, C Xie (2017) Ultraflexible nanoelectronic probes form reliable, glial scar free neural integration Science Advances 3: e1601966在小宇宙查看该单集文稿

35分钟
75
10个月前
EP13. 周立:智慧从何而来——大脑的发育与可塑性

EP13. 周立:智慧从何而来——大脑的发育与可塑性

脑科学连线 BrainCast

公众号图文:https://mp.weixin.qq.com/s/ndI_D-Cw2cdljMuuls0-gQ嘉宾名片周立博士,2010年毕业于华中科技大学,2017年在中科院上海神经科学研究所(脑科学与智能技术卓越创新中心)获得神经科学博士学位(先后在章晓辉实验室、孙衍刚实验室学习工作)。博士论文研究5-HT神经元的活动如何被其它脑区调节。2017年底至今在加州大学旧金山分校(UCSF)的Arnold Kriegstein实验室积累博士后经验,研究人脑皮层早期发育中的微环路。从2018年初至今,作为加州大学旧金山分校博后工会志愿者参与了加州大学博后权利争取与维护。2020年4月至今,与UCSF的郭光猛,UCSC(University of California, Santa Cruz,加州大学圣克鲁兹分校)的马韶蓉建立了“神经科学青年学者云端论坛——云端论脑”,期待与大家进行专业交流和科普互动。喜欢使用开源软件(github.com )实验室主页:kriegsteinlab.ucsf.edu知乎:www.zhihu.com邮箱:[email protected] Publications:Ma CY, Zhong P, Liu DQ, Barger ZK, Zhou L, Chang WC, Kim B, Dan Y (2019) Sleep Regulation by Neurotensinergic Neurons in a Thalamo-Amygdala Circuit. Neuron 103: 1-12. Gao ZR, Chen WZ, Liu MZ, Chen XJ, Wan L, Zhang XY, Yuan L, Lin JK, Wang M, Zhou L, Xu XH, Sun YG (2018) Tac1-expressing neurons in the periaqueductal gray facilitate the itch-scratching cycle via descending regulation. Neuron 101: 45-59. Zhou L, Liu MZ, Li Q, Deng J, Mu D, Sun YG (2017) Organization of Functional Long-Range Circuits Controlling the Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus. Cell Rep. 18:3018-3032. Sun YG, Rupprecht V, Zhou L, Dasgupta R, Seibt F, Beierlein M (2016) mGluR1 and mGluR5 synergistically control cholinergic synaptic transmission in the thalamic reticular nucleus. J Neurosci. 36:7886-7896. Wang JY, Chen F, Fu XQ, Ding CS, Zhou L, Zhang XH, Luo ZG (2014) Caspase-3 cleavage of disheveled induces elimination of postsynaptic structures. Dev. Cell 28:670–684.在小宇宙查看该单集文稿

59分钟
0
10个月前
EP11. 崔东红:冥想对精神疾病的调控

EP11. 崔东红:冥想对精神疾病的调控

脑科学连线 BrainCast

公众号图文:https://mp.weixin.qq.com/s/foJNPGB9-TPdmKFwy6__7A嘉宾名片个人简介崔东红,上海交通大学医学院附属精神卫生中心研究员,博士生导师,上海市重性精神疾病重点实验室执行主任,精神疾病样本库主任。担任中国神经科学学会精神病学基础与临床分会(CSNP)常委兼秘书长,中国CSNP神经调控联盟主席等学术职务。多年来主要从事精神疾病分子机制、生物标记物及药物代谢副作用及机理研究,近年来还开展了冥想的神经调控方面研究,与此同时她本人也是冥想实修者。联系方式邮箱:[email protected]电话:18017311051代表论文1. Jiang H, He B, Guo X, Wang X, Guo M, Wang Z, Xue T, Li H, Xu T, Ye S, Suma D, Tong S*, Cui D*.Brain-Heart Interactions Underlying Traditional Tibetan Buddhist Meditation. Cereb Cortex. 2020 Mar 21;30(2):439-450.2. Lin GN#*;Guo S#;Tan X;Wang W;Qian W;Song W;Wang J;Yu S;Wang Z;Cui D*;Wang H*;PsyMuKB: An Integrative De Novo Variant Knowledge Base for Developmental Disorders, Genomics Proteomics Bioinformatics, 2019, Aug :17 (4), 453-464 .3. Fang Y, Wang W, Zhu C, Lin GN, Cheng Y, Zou J*, Cui D*. Use of tobacco in schizophrenia: A double-edged sword. Brain Behav. 2019 Nov;9(11):e01433.4. Cui D#*;Peng Y#;Zhang C#;Li Z#;Su Y;Qi Y;Xing M1, Li J;Kim GE;Su KN;Xu J;Wang M;Ding W;Piecychna M;Leng L;Hirasawa M;Jiang K;Young L;Xu Y;Qi D*;Bucala R;Macrophage migration inhibitory factor mediates metabolic dysfunction induced by atypical antipsychotic therapy, J Clin Invest, 2018 ,Nov 1;128(11):4997-5007..5. Lin Y, Peng Y, Zhou R, Cui D*. Serum IL-1ra, a novel biomarker predicting olanzapine-induced hypercholesterolemia and hyperleptinemia in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt A):71-78.6. Zhang J, Pan Z, Gui C, Cui D*. Analysis on speech signal features of manic patients. J Psychiatr Res. 2018 Mar;98:59-63.7. Su Y, Ding W, Xing m, Qi D, Li Z*, Cui D*.The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia. Mol Neurobiol. 2017 Aug;54(6):4806-48128. Li Z#;Wang Z;Zhang C;Chen J;Su Y;Huang J;Yi Z;Yuan C;Hong W;Wang Y;Wu Z;Hu Y;Cao L;Peng D;Guan Y;Zou Y;Yu S*;Cui D*;Fang Y*;Reduced ENA78 levels as novel biomarker for major depressive disorder and venlafaxine efficiency: Result from a prospective longitudinal study, Psychoneuroendocrinology, 2017, Jul;81:113-1219. Cui DH#, Jiang KD, Jiang SD, Xu YF, Yao H. The tumor suppressor adenomatous polyposis coli gene is associated with susceptibility to schizophrenia. Mol Psychiatry. 2005 Jul;10(7):669-77在小宇宙查看该单集文稿

54分钟
0
10个月前
EP10. 刘鼎:解码爱的神经生物学机制

EP10. 刘鼎:解码爱的神经生物学机制

脑科学连线 BrainCast

公众号图文:https://mp.weixin.qq.com/s/EclHOSPmFGnlQaCiho4bww嘉宾名片个人简介:刘鼎博士,2010年毕业于河南大学,2016在中科院上海神经科学研究所获得博士学位。其博士论文发表在Science杂志,阐述了大脑前额叶处理 “工作记忆” 的新机制。2016年至今在哈佛大学分子与细胞生物系做博士后,专注于动物社交本能和孤独感的研究。曾获得研究生国家奖学金,吴瑞奖学金,中科院院长奖,Jane Coffin Childs 博士后奖学金等荣誉。2015年应邀参加德国林岛诺贝尔奖获得者大会。2017-2019 国际青少年科学影像大赛评委;2018-2019 国际中学生科学与工程竞赛(ISEF)评委。联系方式:[email protected]实验室网站:www.mcb.harvard.edu代表论文:1.    Liu D*, Gu X*, Zhu J*, Zhang X, Han Z, Yan W, Cheng Q, Hao J, Fan H, Hou R, Chen Z, Chen Y, Li CT. (2014) Medial prefrontal activity during delay period contributes to learning of a working memory task. Science, 346, 458-63.2.    Liu D, Gu X, Zhu J, Li CT. (2014) Functional contribution of medial prefrontal cortex in working memory task learning. Chinese Journal of Cell Biology 36, 1597–1600.3.    Yao H, Wang T, Deng J, Liu D, Li X, and Deng J. (2014). The development of blood-retinal barrier during the interaction of astrocytes with vascular wall cells. Neural Regen Res 9, 1047-54.在小宇宙查看该单集文稿

43分钟
0
10个月前

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