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用功能磁共振（fMRI）影像检测VR在不同脑区活跃度上的影响。绿线分别圈出了前扣带回皮层、初级体感皮层、次级体感皮层、脑岛、丘脑（来自从上到下）。图中左侧的五个图像（每个研究区域一个）代表没有使用VR时的大脑活动。图右半部的图像表示在使用VR时与疼痛相关的大脑活动。使用VR的受试者表现出与疼痛相关的大脑活动减少。

来源：Hoffman HG, Richards TL, Coda B, Bills AR, Blough D, Richards AL, Sharar SR. Modulation of thermal pain-related brain activity with virtual reality: evidence from fMRI. Neuroreport. 2004 Jun 7;15(8):1245-8

Morton Heilig在1950s年代发明的沉浸式模拟现实体验游戏，1962年获得了专利。

参考资料：

[1] Chuan A, Zhou JJ, Hou RM, Stevens CJ, Bogdanovych A. Virtual reality for acute and chronic pain management in adult patients: a narrative review. Anaesthesia. 2021 May;76(5):695-704.

[2] Tashjian V, Mosadeghi S, Howard A, Lopez M, Dupuy T, Reid M, Martinez B, Ahmed S, Dailey F, Robbins K, Rosen B, Fuller G, Danovitch I, IsHak W, Spiegel B

Virtual Reality for Management of Pain in Hospitalized Patients: Results of a Controlled Trial. JMIR Ment Health 2017;4(1):e9. 

[3] Modifying the Matrix: Virtual Reality, Perception and Pain. https://www.youtube.com/watch?v=MJ6dMM-CQ2E

[4] Dahlquist LM, Herbert LJ, Weiss KE, Jimeno M. Virtual-reality distraction and cold-pressor pain tolerance: does avatar point of view matter?. Cyberpsychol Behav Soc Netw. 2010;13(5):587-591. 

[5] 纤维肌痛介绍：

https://zhuanlan.zhihu.com/p/20867138

片头曲&背景音乐: B Minor, Probably. 

编曲: 兔子

片尾曲: I Lived

原唱: OneRepublic; 翻唱: Evan Cole