想了解更多关于身体的秘密吗？关节灵活你知道，但代谢灵活听说过吗？断食、低碳饮食为何备受追捧？这一切，都离不开“代谢灵活度”的神奇力量！想象一下，我们的身体如同高性能混合动力车，轻松驾驭各类燃料，这能力，古老而又关键。从肠道寄生虫的生存智慧，到人类应对食物稀缺的进化策略，代谢灵活度不仅是生存之道，更是健康风向标。然而，现代生活让它遭受挑战，营养过剩成了新危机。代谢失灵，肥胖、糖尿病接踵而至，健康警钟长鸣。揭秘时刻来了！身体如何在糖与脂肪间自如转换？紧急时刻，甚至能“变废为宝”，维持血糖平衡。能量工厂线粒体，是这一切运作的核心。想知道更多？比如，代谢卡壳对身体的连环冲击，从血糖失调到细胞损伤，乃至肥胖与疾病的紧密联系？别急，咱们还得聊聊影响代谢灵活的幕后推手：胰岛素、骨骼肌、脂肪组织，还有日夜作息的节奏感。饿了咋办？吃饱了又该如何？运动、休息，它们如何重塑你的代谢魔力？ 关键在此：理解代谢灵活背后的科学逻辑，调整生活方式，让身体再次回归健康节拍！
00:41INTRO
01:57什么是“代谢灵活度”metabolic flexibility
05:28能量来源、能量系统、代谢路径 fuel source/ energy system/ metabolicpathways
11:35代谢不灵活的危害 metabolic inflexibility
15:26影响代谢灵活度的重要因素：1. 饭后&空腹 feeding&fasting
18:442. 肝脏、骨骼肌、脂肪组织 liver/skeleton muscle/wat
23:343. 运动 exercises
27:204. 睡眠 sleep
28:26如何提高代谢灵活度
34:01OUTRO
BGM:I Don’t Recognise You - NewDad
References:
1. Metabolic flexibility www.cambridge.org
2. Metabolic Flexibility in Healthand Disease
www.cell.com(17)30220-6.pdf
3. Metabolic Flexibility andinsulin resistance
journals.physiology.org
4. Metabolic Flexibility as anAdaptation to Energy Resources and Requirements in Health and Disease
academic.oup.com
5. Metabolic Flexibility and ItsImpact on Health Outcomes www.sciencedirect.com
6. Metabolic Flexibility as anAdaptation to Energy Resources and Requirements in Health and Disease
academic.oup.com
7. Metabolic Flexibility and ItsImpact on Health Outcomes
www.sciencedirect.com
8. Mitochondrial (Dys)function andInsulin Resistance: From Pathophysiological Molecular Mechanisms to the Impactof Diet
www.frontiersin.org
9. Mitochondrial dysfunction andoxidative stress in metabolic disorders - A step towards mitochondria basedtherapeutic strategies
pubmed.ncbi.nlm.nih.gov
10.High glucose-induced oxidative stress and mitochondrial dysfunctionin neurons
faseb.onlinelibrary.wiley.com
11.Effects of acute lipid overload on skeletal muscle insulinresistance, metabolic flexibility, and mitochondrial performance
www.ncbi.nlm.nih.gov
12.Prolonged Fasting Identifies Skeletal Muscle MitochondrialDysfunction as Consequence Rather Than Cause of Human Insulin Resistance
diabetesjournals.org
13.Metabolic flexibility during sleep
www.nature.com